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Mouse Mdm2 p53 Binding Protein Homolog (MDM2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Mdm2 p53 Binding Protein Homolog (MDM2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse MDM2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
E3 ubiquitin-protein ligase Mdm2 functions as an E3 ubiquitin-protein ligase that facilitates the ubiquitination of p53/TP53, marking it for degradation by the proteasome. By binding to the transcriptional activation domain of p53/TP53 and p73/TP73, Mdm2 inhibits cell cycle arrest and apoptosis mediated by these proteins. Acting as a key negative regulator of p53, Mdm2 forms a complex with p53 to promote its ubiquitination and subsequent degradation. This regulatory mechanism is vital in mouse development and carcinogenesis. Mdm2 knockout mice often face embryonic lethality due to unchecked p53 activity, resulting in cell cycle arrest and apoptosis.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Kook, Seunghyi et al. "Mdm2 enhances ligase activity of parkin and facilitates mitophagy." Scientific reports vol. 10,1 5028. 19 Mar. 2020.