Mouse Matrix Metalloproteinase 2 (MMP2) ELISA Kit-Sandwich

The 72 kDa type IV collagenase, known as MMP2, is a versatile metalloproteinase involved in processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. Besides breaking down extracellular matrix proteins, MMP2 can also act on non-matrix proteins like big endothelial 1 and beta-type CGRP, promoting vasoconstriction. In mice, MMP2 has diverse roles, impacting bone development, tissue repair, immune response, and the progression of various diseases. It is crucial for bone development and repair, as mice lacking MMP2 exhibit reduced bone density, destruction of articular cartilage, and abnormal development of long bones and craniofacial features, resembling symptoms of human osteogenesis imperfecta (MOA).