Mouse Low Density Lipoprotein Receptor Related Protein 1 (LRP1) ELISA Kit-Sandwich

Low Density Lipoprotein Receptor Related Protein 1 (LRP1) is an endocytic receptor that plays a critical role in endocytosis and the phagocytosis of apoptotic cells. Essential for early embryonic development, LRP1 is also involved in maintaining cellular lipid balance. It contributes to the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), and it is crucial for the local metabolism of complexes formed between plasminogen activators and their endogenous inhibitors, acting as an alpha-2-macroglobulin receptor. In mice, LRP1 has diverse functions, impacting the nervous system, metabolism, vascular health, immune response, and bone development. A deficiency in LRP1 leads to severe behavioral and motor issues in mice, such as hyperactivity, tremors, and rigidity, potentially linked to synaptic dysfunction.