Mouse Kininogen 1 (KNG1) ELISA Kit-Sandwich

Kininogens are known as inhibitors of thiol proteases. High molecular weight (HMW) kininogen plays a crucial role in blood coagulation by optimally positioning prekallikrein and factor XI adjacent to factor XII. It also inhibits thrombin- and plasmin-induced platelet aggregation. On the other hand, low molecular weight (LMW) kininogen inhibits platelet aggregation but is not involved in blood clotting like HMW-kininogen. In mice, kininogen-1 (mKNG1) is an essential component of the contact system, regulating thrombosis and inflammatory responses. In mouse models, the absence of mKNG1 results in the loss of LMW kinins (LMWK) and HMW kinins (HMWK) in plasma, significantly extending the duration of atherosclerosis-induced vascular occlusion, highlighting mKNG1's vital role in thrombosis. Upregulation of mKNG1 in brain microvessels is closely linked to an enhanced coagulation cascade, reflecting its role in maintaining vascular homeostasis and preventing excessive coagulation. The expression level of mKNG1 is connected to various disease states; for instance, it is significantly reduced in diabetic patients, which may be associated with the progression of diabetic nephropathy.