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Mouse Kallikrein-8 (KLK8) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Kallikrein-8 (KLK8) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse KLK8 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Kallikrein-8 is a serine protease that can degrade various proteins, including casein, fibrinogen, kininogen, fibronectin, and type IV collagen. It also cleaves L1CAM in response to heightened neural activity and induces neurite outgrowth and fasciculation in cultured hippocampal neurons. KLK8 plays a crucial role in skin keratinogenesis, participating in the shedding of the stratum corneum by promoting keratinocyte proliferation and differentiation. In wild-type mice (WT), treatment with 12-O-tetradodecanoyl-13-acetate (TPA) significantly increased KLK8 mRNA and protein levels. In contrast, KLK8 knockout mice (Klk8−/−) exhibited reduced proliferation and an increased number of cell layers in the stratum corneum.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.