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Mouse Interleukin 22 Receptor Alpha 2 (IL22Ra2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Interleukin 22 Receptor Alpha 2 (IL22Ra2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse IL22Ra2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Interleukin-22 receptor subunit alpha-2 serves as a receptor for IL22. It binds to IL22, preventing its interaction with the functional IL-22R complex, thereby inhibiting IL22's activity in vitro. It potentially acts as an IL22 antagonist, playing a significant role in regulating inflammatory responses. In mice, the function of IL22RA2 (IL-22 binding protein 2) is largely associated with the IL-22BP it encodes-a soluble IL-22 receptor that inhibits IL-22's biological activity by competing for its ligand, IL-22. Mice with an IL22ra2 gene knockout (Il22ra2−/−) exhibit more severe skin inflammation, such as psoriasis-like symptoms, characterized by thickening of the stratum corneum, scaling, keratinization of hair follicles, and the formation of microabscesses.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Fukaya, Tomohiro et al. "Pivotal Role of IL-22 Binding Protein in the Epithelial Autoregulation of Interleukin-22 Signaling in the Control of Skin Inflammation." Frontiers in immunology vol. 9 1418. 21 Jun. 2018.