Mouse Interleukin 10 (IL10) ELISA Kit-Sandwich

Interleukin-10 (IL-10) is a key immune-regulating cytokine with strong anti-inflammatory functions, acting on numerous immune system cells to minimize tissue damage from inflammation. IL-10 operates by binding to its heterotetrameric receptor, composed of IL10RA and IL10RB, which triggers JAK1 and STAT2-mediated phosphorylation of STAT3. Recognized as a vital immunomodulatory factor, IL-10 primarily functions to inhibit inflammatory responses and promote immune tolerance. Specifically, it suppresses the activation and effector functions of T cells, monocytes, and macrophages, thereby controlling and resolving inflammation. Additionally, IL-10 plays a role in regulating the growth and differentiation of various blood cells. The functions of IL-10 have been extensively studied in mouse models. During parasitic infections, such as human leukocytosis, IL-10 can inhibit inflammatory cell activation and, in some cases, provide protective effects through receptor-mediated signaling involving IL-10R1 and IL-10R2.