Mouse Interleukin 1 Receptor Type I (IL1R1) ELISA Kit-Sandwich

Interleukin-1 receptor type 1 (IL-1R1) serves as a receptor for IL1A, IL1B, and IL1RN. Upon binding with interleukin-1, it associates with the coreceptor IL1RAP to form a high-affinity interleukin-1 receptor complex, facilitating interleukin-1-dependent activation of NF-kappa-B, MAPK, and other pathways. This signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 through the TIR domains of the receptor/coreceptor subunits. In mice, IL-1R1 performs a variety of biological functions, including involvement in inflammatory responses, immune regulation, metabolic regulation, and disease development. Its expression and functional differences across various tissues and cell types underscore IL-1R1's crucial role in maintaining bodily homeostasis and disease defense.