Mouse Insulin Like Growth Factor Binding Protein 2 (IGFBP2) ELISA Kit-Sandwich

Insulin-like growth factor-binding protein 2 (IGFBP2) is a versatile protein that plays a pivotal role in regulating the availability of insulin-like growth factors (IGF1 and IGF2) to their receptors. This regulation influences IGF-mediated cellular processes, including proliferation, differentiation, and apoptosis, in a cell-type-specific manner. In mice, IGFBP2 has extensive and complex functions spanning various areas, such as metabolism, tumor development, immunity, bone remodeling, muscle growth, and cardiovascular health. Its expression is closely linked to metabolic health; for example, high levels of IGFBP2 are associated with obesity and insulin resistance, while low levels may encourage adipose tissue accumulation. Moreover, IGFBP2 expression in the liver is subject to epigenetic regulation, including changes in DNA methylation levels that influence its expression and consequently affect metabolic health.