Mouse Hypoxia Inducible Factor 2 Alpha (HIF2a) ELISA Kit-Sandwich

Endothelial PAS domain-containing protein 1 (EPAS1, also known as hypoxia inducible factor 2 alpha) functions as a transcription factor that plays a crucial role in inducing genes responsive to oxygen levels. It specifically regulates the expression of vascular endothelial growth factor (VEGF) and is believed to be essential in the formation of blood vessels and the lung's tubular system. In mice, EPAS1 has diverse and intricate roles, influencing areas such as embryonic development, cardiovascular protection, metabolic regulation, inflammatory response, and tumor growth. It is a key player in managing hypoxia tolerance in mice; for instance, in mice lacking Phd1, the absence of EPAS1 entirely removed their ability to tolerate low oxygen conditions, resulting in a marked rise in necrotic muscle tissue areas. Furthermore, EPAS1 facilitates the onset of colitis in the intestinal lining by triggering inflammatory processes.