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Mouse High Molecular Weight Kininogen (HMWK) ELISA Kit-Sandwich

Cat. No.EK6F639

Product TypeAnimal Immunoassay Kits

Size

Product Overview

BioVenic Mouse High Molecular Weight Kininogen (HMWK) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse HMWK in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich
Specificity The assay kit is specific for Mouse High Molecular Weight Kininogen (HMWK).
Target Species Mouse
Species Reactivity Mouse
Detection Range 0.63-40 ng/mL
Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%
Assay Time Around 90 min
Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

High Molecular Weight Kininogen (HK) performs various biological functions in mice, primarily related to thrombosis, anti-inflammation, anticoagulation, and anti-tumor activities. HK is a central component of the plasma kinin-kinase system (KKS). It contributes to the activation of the coagulation process by binding to coagulation factor XI and prekallikrein, thereby promoting the initiation of the contact activation pathway. In mice, the absence of HK results in abnormal coagulation functions, such as prolonged partial thromboplastin time (APTT) and prothrombin time, highlighting its crucial role in the coagulation and fibrinolysis systems. The light chain of HK, known as HKa, possesses anticoagulant properties and can inhibit the binding of fibrinogen to cell adhesion molecules on neutrophils and platelets, thus preventing thrombosis.

Target/Biomarker Mouse HMWK
Target Synonym Williams-Fitzgerald-Flaujeac Factor; Fitzgerald Factor; HMWK-Kallikrein Factor

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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