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Mouse Hexokinase 2 (HK2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Hexokinase 2 (HK2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse HK2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Hexokinase-2 facilitates the phosphorylation of hexoses like D-glucose and D-fructose into hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively). It initiates the glycolytic pathway by phosphorylating D-glucose to produce D-glucose 6-phosphate. In mice, the absence of HK2 results in disrupted glucose metabolism, characterized by impaired insulin signaling and decreased glucose utilization, mirroring features of type 2 diabetes. Additionally, diminished HK2 expression in adipose tissue contributes to hyperglycemia and insulin resistance, underscoring its vital role in maintaining glucose homeostasis. In models of inflammation and brain injury, HK2 expression is significantly upregulated in microglia.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.