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Mouse Heme Oxygenase 2, Decycling (HO2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Heme Oxygenase 2, Decycling (HO2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse HO2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Heme oxygenase 2 (HO-2) facilitates the oxidative cleavage of heme at the alpha-methene bridge carbon, releasing it as carbon monoxide (CO) and producing biliverdin IXalpha, while also liberating the central heme iron as ferrous iron. Under conditions of oxidative stress, HO-2 helps reduce oxidative damage and enhances cell survival. For instance, HO-2-deficient mice exhibit elevated oxidative damage markers, such as increased hemoglobin and ferritin content, when exposed to hyperoxia (95% O2), without a significant rise in antioxidant enzyme activity. In an intracerebral hemorrhage model, HO-2-deficient mice display larger brain lesion volumes, increased brain edema, and neuronal death, along with elevated ROS levels and vascular dysfunction.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.