Mouse Growth Differentiation Factor 5 (GDF5) ELISA Kit-Sandwich

Growth/differentiation factor 5 is a growth factor that participates in bone and cartilage formation. During cartilage development, it regulates the differentiation of chondrogenic tissue through two pathways. Firstly, it promotes chondrogenic tissue differentiation by binding with high affinity to BMPR1B and with lower affinity to BMPR1A. This binding leads to the phosphorylation of the SMAD1-SMAD5-SMAD8 complex and subsequent SMAD protein signal transduction. GDF5 plays a crucial role in skeletal development, particularly in the formation of bones, cartilage, and joints. Research indicates that mutations in the GDF5 gene can result in short limbs (brachypodism) in mice, characterized by reduced limb bone length and abnormalities such as the fusion of finger bones.