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Mouse Granulin (GRN) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Granulin (GRN) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GRN in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
In mice, Granulin (GRN) primarily functions in relation to prefrontal and temporal degenerative diseases, such as frontotemporal dementia (FTD). In a mouse model lacking PGRN (Grn^−/−), Granulin expression can significantly ameliorate neuropathological changes caused by PGRN deficiency, including inflammatory responses, lysosomal dysfunction, and synaptic loss. Granulin can normalize abnormal lysosomal protein levels, such as cathepsin Z and galectin-3, resulting from PGRN deficiency and improve lipid metabolism disorders linked to lysosomal function. By correcting lipid metabolism abnormalities, such as changes in BMP and GlcSph levels, Granulin helps prevent lipofuscin accumulation, a pathological characteristic of neurodegenerative diseases like FTD.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.