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Mouse Glycoprotein 130 (gp130) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Glycoprotein 130 (gp130) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse gp130 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
gp130 influences the differentiation of osteoblasts and osteoclasts through distinct signaling pathways, impacting both bone density and size. Research indicates that a deficiency in gp130 results in reduced bone density. Its stimulatory effect on osteoblasts is primarily mediated via the STAT3 signaling pathway, whereas its inhibitory effect on osteoclasts operates through the SHP2/MAPK signaling pathway. In mice, gp130 serves multiple functions, including regulating bone metabolism, immune responses, inflammation, and liver function. While gp130-deficient mice exhibit normal trabecular bone volume (BV/TV) and bone turnover rate (TBS), their bone length is reduced due to the premature closure of the periosteal growth plate.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.