Mouse Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1) ELISA Kit-Sandwich

The GluA1 subunit, encoded by GRIA1, is an essential component of the AMPA-type glutamate receptor, which is abundantly present in the central nervous system, particularly in regions like the hippocampus and thalamus. AMPA receptors play a vital role in synaptic plasticity and the formation of learning and memory by regulating the opening of ion channels. Research indicates that Gria1 knockout mice (Gria1−/−) display significant synaptic plasticity defects, including the loss of long-term potentiation (LTP) in the hippocampus, which is closely linked to impaired AMPA receptor function. These knockout mice exhibit neurobehavioral traits associated with psychiatric disorders, such as anxiety, learning disabilities, heightened habituation, and heightened responses to novel environments. In the open field test, Gria1−/− mice demonstrate increased activity levels but show reduced social behavior and habituation learning ability, suggesting their behavioral patterns may be linked to conditions like schizophrenia or bipolar disorder.