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Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Glutamate Cysteine Ligase, Catalytic (GCLC) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GCLC in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Glutamate-cysteine ligase catalyzes the ATP-dependent bonding of L-glutamate and L-cysteine, initiating and controlling the rate-limiting step in glutathione biosynthesis. In mice, Gclc is vital for synthesizing glutathione, regulating oxidative stress, and playing a crucial role in the development and pathology of various tissues. Mice with a liver-specific knockout of Gclc exhibit severe steatosis and liver failure. These mice begin to experience hepatocyte apoptosis and inflammatory responses by postnatal day 21 (PND21) and typically succumb to liver failure around PND30. Additionally, a complete loss of Gclc in the mouse central nervous system results in mitochondrial dysfunction and neurodegenerative diseases.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.