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Mouse GATA Binding Protein 3 (GATA3) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse GATA Binding Protein 3 (GATA3) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GATA3 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Trans-acting T-cell-specific transcription factor GATA-3 acts as a transcriptional activator, binding to the enhancer regions of the T-cell receptor alpha and delta genes. It specifically binds to the consensus sequence 5'-AGATAG-3' and is essential for T-helper 2 (Th2) cell differentiation after immune and inflammatory responses. GATA-3 also positively regulates the expression of ASB2. Additionally, GATA-3 is vital for the functional maturation of mouse cochlear inner hair cells (IHCs). A deficiency in GATA-3 results in IHCs failing to develop mature characteristics, such as basilar membrane current acquisition, maintenance of presynaptic currents, and synaptic connection formation. This leads to increased auditory brainstem response (ABR) thresholds, indicative of hearing impairment.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.