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Mouse G Protein Coupled Receptor Kinase 5 (GRK5) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse G Protein Coupled Receptor Kinase 5 (GRK5) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GRK5 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
G protein-coupled receptor kinase 5 (GRK5) is a serine/threonine kinase that predominantly phosphorylates activated G-protein-coupled receptors (GPCRs). GRK5 targets various GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (specifically the Gi-coupled M2/M4 subtypes), dopamine receptors, and opioid receptors. In mice, cardiac-specific overexpression of GRK5 (TgGRK5) results in decreased cardiac function, reduced left ventricular ejection fraction, ventricular dilatation, and increased mortality. Conversely, GRK5 knockout mice (GRK5KO) exhibit improved cardiac function, with reductions in myocardial hypertrophy and fibrosis.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.