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Mouse Elastase 2, Neutrophil (ELA2) ELISA Kit-Sandwich

Cat. No.EK5F416

Product TypeAnimal Immunoassay Kits

Size

Product Overview

BioVenic Mouse Elastase 2, Neutrophil (ELA2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ELA2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich
Specificity The assay kit is specific for Mouse Elastase 2, Neutrophil (ELA2).
Target Species Mouse
Species Reactivity Mouse
Detection Range 0.17-10 ng/mL
Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%
Assay Time Around 90 min
Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

Neutrophil elastase is a serine protease that influences the functions of natural killer cells, monocytes, and granulocytes by inhibiting C5a-dependent neutrophil enzyme release and chemotaxis, and promoting blood coagulation. In mice, neutrophil elastase (NE) is involved in various functions, such as inflammation, tumor development, skin lesions, and infection defense. Research indicates that NE significantly contributes to non-infectious chronic inflammation; for instance, it works in conjunction with proteinase 3 (PR3) to enhance the inflammatory response by breaking down the anti-inflammatory protein progranulin. Additionally, NE induces pain and inflammation by activating the PAR2 and TRPV4 ion channels.

Target/Biomarker Mouse ELA2
Target Synonym ELANE; HLE; HNE; NE; PMN-E; Neutrophil Elastase; Medullasin; Polymorphonuclear Leukocyte Elastase; Bone Marrow Serine Protease; Human Leukocyte Elastase; PMN Elastase
Gene ID 50701
UniProt ID Q3UP87

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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