Mouse Dopamine Transporter (DAT) ELISA Kit-Sandwich

The sodium-dependent dopamine transporter facilitates the transport of dopamine in a manner dependent on sodium and chloride ions. It also performs similar transport functions for norepinephrine (noradrenaline). In mice, the dopamine transporter encoded by the SLC6A3 gene is primarily responsible for the reuptake of dopamine, which is crucial for maintaining balanced dopamine levels. Loss of function or reduced expression of this transporter leads to elevated dopamine levels, affecting normal nervous system functionality. Mice with a knockout of the SLC6A3 gene exhibit pronounced hyperactivity and heightened sensitivity to certain stimuli. For instance, these knockout mice display increased exploratory behavior in new environments but struggle with adapting to these environments.