Mouse DNA Methyltransferase 3B (DNMT3B) ELISA Kit-Sandwich

DNA (cytosine-5)-methyltransferase 3B is crucial for genome-wide de novo methylation and is vital for establishing DNA methylation patterns during development. This process is coordinated with the methylation of histones and may preferentially target nucleosomal DNA within the nucleosome core region. Additionally, it might act as a transcriptional co-repressor by associating with CBX4, independently of DNA methylation. Dnmt3b is a key DNA methyltransferase in mammals, responsible for initiating new methylation patterns and maintaining genomic imprinting. Research indicates that Dnmt3b is essential for embryonic development, with its absence leading to embryonic lethality in the late stages due to a lack of methylation in the repetitive sequences of chromosome central regions. Furthermore, Dnmt3b displays circadian expression patterns in mouse liver tissue, a trait that may be closely linked to the liver's metabolic function and genomic stability.