Mouse Cyclin Dependent Kinase 8 (CDK8) ELISA Kit-Sandwich

Cyclin-dependent kinase 8 (CDK8) is integral to the Mediator complex, acting as a coactivator essential for the regulated transcription of almost all genes that depend on RNA polymerase II. This Mediator serves as a link, delivering information from gene-specific regulatory proteins to the core RNA polymerase II transcription machinery. In mice, CDK8 has a broad range of complex roles, including significant contributions to embryonic development, adult tissue homeostasis, transcriptional regulation, cancer development, and immune system regulation. Its importance in embryonic development is highlighted by studies demonstrating that a complete knockout of CDK8 results in lethal defects prior to implantation (embryonic days 2.5 to 3), characterized by preimplantation embryo fragmentation and an inability to compact.