Mouse Cross Linked N-Telopeptide of Type I Collagen (NTXI) ELISA Kit-Competitive

NTx serves as a marker of bone resorption, with its levels indicating the bone resorption rate. In mouse models, the degradation and remodeling of type I collagen are crucial for tissue repair. Mutations at collagenase cleavage sites can hinder type I collagen degradation, impacting normal tissue healing and repair. In such scenarios, NTx may be a biomarker indicating collagen degradation during tissue repair. NTx generation involves cross-linking reactions between type I collagen molecules. Research indicates that the cross-linking process of type I collagen is tightly regulated, with lysine residues in its molecular structure being key sites for these cross-links. These cross-linking reactions not only influence collagen stability but also potentially regulate the receptor binding activity of cytokines, such as PEDF, thereby indirectly affecting cell survival or death.