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Mouse Complement Component 1, Q Subcomponent A (C1qA) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Complement Component 1, Q Subcomponent A (C1qA) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse C1qA in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
C1q combines with the proenzymes C1r and C1s to form C1, the initial component of the serum complement system. The collagen-like regions of C1q engage with the calcium-dependent C1r2C1s2 proenzyme complex, enabling efficient activation of C1 when the globular heads of C1q bind with the Fc regions of IgG or IgM antibodies in immune complexes. C1qa is an integral part of the C1q protein complex, which is vital in the classical complement activation pathway. Research has demonstrated that a deficiency in C1qa is strongly linked to the onset of systemic lupus erythematosus-like symptoms in mice, with C1qa-deficient mice displaying antinuclear antibodies and proliferative glomerulonephritis, symptoms akin to human systemic lupus erythematosus.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.