Mouse Collagen Type III (COL3) ELISA Kit-Sandwich

Type III collagen is a primary fibrillar collagen present in the early embryo and throughout embryonic development, and it is a dominant component of the extracellular matrix in various organs and the skin of adult mice. It is crucial for the normal fibrillation of type I collagen and is vital for the proper development of the cardiovascular system. Additionally, type III collagen interacts with the G protein-coupled receptor GPR56 to regulate cerebral cortex development and stratification. In mice, type III collagen supports embryonic development, aids in tissue repair, participates in disease processes, and maintains skin health. It is significant in various disease models; for instance, in a mouse model of type IV Ehlers-Danlos syndrome, mutations in the COL3A1 gene cause reduced expression of type III collagen, leading to severe complications such as aneurysms.