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Mouse Claudin 5 (CLDN5) ELISA Kit-Sandwich

Name: Mouse Claudin 5 (CLDN5) ELISA Kit-Sandwich
SKU: EK6F481
Rating: 5 (1 reviews)

Cat. No.EK6F481

Product TypeAnimal Immunoassay Kits

Size

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Product Overview

BioVenic Mouse Claudin 5 (CLDN5) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CLDN5 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich

Specificity The assay kit is specific for Mouse Claudin 5 (CLDN5).

Target Species Mouse

Species Reactivity Mouse

Detection Range 0.32-20 ng/mL

Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%

Assay Time Around 90 min

Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

Claudin-5 is essential for the tight junction-specific sealing of intercellular spaces, functioning through calcium-independent cell adhesion. In mice, Claudin-5 is primarily involved in the formation and maintenance of the blood-brain barrier (BBB). As a key cell adhesion molecule in tight junctions, Claudin-5 is expressed in brain endothelial cells, significantly affecting the selective permeability to small molecules. Claudin-5-deficient mice die shortly after birth due to impaired BBB function. In adult mice, the knockout of Claudin-5 results in BBB disruption, leading to spontaneous epileptic seizures and abnormal behavior.

Target/Biomarker Mouse CLDN5

Target Synonym AWAL; BEC1; CPETRL1; TMVCF; Transmembrane Protein Deleted In Velocardiofacial Syndrome; Transmembrane protein deleted in VCFS

Gene ID 12741

UniProt ID O54942

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

Castro Dias, Mariana et al. "Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers." International journal of molecular sciences vol. 20,21 5372. 29 Oct. 2019.