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Mouse Claudin 2 (CLDN2) ELISA Kit-Sandwich

Cat. No.EK5F988

Product TypeAnimal Immunoassay Kits

Size

Product Overview

BioVenic Mouse Claudin 2 (CLDN2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CLDN2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich
Specificity The assay kit is specific for Mouse Claudin 2 (CLDN2).
Target Species Mouse
Species Reactivity Mouse
Detection Range 0.17-10 ng/mL
Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%
Assay Time Around 90 min
Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

Claudin-2 forms paracellular channels by polymerizing into tight junction strands that contain cation- and water-selective channels, facilitating epithelial permeability through a process called paracellular tight junction permeability. In the intestinal epithelium, it enables the flux of sodium and water from the peritoneal side to the intestinal lumen, thereby regulating nutrient absorption and aiding in the clearance of enteric pathogens as part of the mucosal immune response. In the mouse colon, the expression level of Claudin-2 correlates with inflammatory responses. For instance, following Salmonella infection, Claudin-2 expression increases significantly, which is linked to bacterial invasion and disruption of the intestinal barrier. Claudin-2 is also involved in the reabsorption of Na+ and Cl− in the mouse intestine, which is crucial for maintaining intestinal homeostasis and preventing fluid loss.

Target/Biomarker Mouse CLDN2
Target Synonym SP82
Gene ID 12738
UniProt ID O88552

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Zhang, Yong-guo et al. "Salmonella infection upregulates the leaky protein claudin-2 in intestinal epithelial cells." PloS one vol. 8,3 (2013): e58606.
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