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Mouse Chitinase 1 (CHIT1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Chitinase 1 (CHIT1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CHIT1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Chitotriosidase-1 is an enzyme that degrades chitin, chitotriose, and chitobiose, and is likely involved in defending against nematodes and other pathogens. As a mammalian-specific glycoside hydrolase, CHIT1 breaks down chitosan, a polysaccharide integral to the cell walls of many pathogens, including fungi and bacteria. By degrading chitosan, CHIT1 hampers the growth and invasion of these pathogens, thereby enhancing immune defense. For instance, CHIT1-deficient mice demonstrate a significant reduction in renal fungal burden in cases of systemic candidiasis, indicating that CHIT1 plays a crucial role in antifungal immunity and aids in limiting bacterial spread.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Schmitz, Nicholas A et al. "Chitotriosidase Activity Is Counterproductive in a Mouse Model of Systemic Candidiasis." Frontiers in immunology vol. 12 626798. 16 Mar. 2021.