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Mouse Cathepsin Z (CTSZ) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Cathepsin Z (CTSZ) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CTSZ in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Cathepsin Z demonstrates both carboxy-monopeptidase and carboxy-dipeptidase activities, enabling it to produce kinin potentiating peptides. Research indicates that mice lacking Cathepsin Z show a marked decrease in neuroinflammatory responses and IL-1β levels in the experimental autoimmune encephalomyelitis (EAE) model. Additionally, these mice experience significantly reduced demyelination and inflammatory responses in spinal cord tissue following EAE induction. Cathepsin Z (also known as Cathepsin X) primarily functions in mice to regulate neuroinflammation and immune response, particularly in disease models such as multiple sclerosis (MS) and respiratory silicosis.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Allan, Euan R O et al. "A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis." Journal of neuroinflammation vol. 14,1 103. 10 May. 2017.