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Mouse Catenin Beta 1 (CTNNb1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Catenin Beta 1 (CTNNb1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CTNNb1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Catenin Beta 1 is a crucial downstream component of the canonical Wnt signaling pathway. When Wnt is absent, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK3B, promoting the phosphorylation of N-terminal Ser and Thr residues and the ubiquitination of CTNNB1 via BTRC, leading to its degradation by the proteasome. In the presence of a Wnt ligand, CTNNB1 is not ubiquitinated and instead accumulates in the nucleus, where it functions as a coactivator for transcription factors of the TCF/LEF family, activating Wnt-responsive genes. In mice, CTNNB1 plays a significant role in development, reproduction, cancer occurrence, and neurobehavior.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.