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Mouse Caspase 1 (CASP1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Caspase 1 (CASP1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CASP1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Caspase-1 is a thiol protease that participates in various inflammatory processes by cleaving proteins like the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18), as well as the pyroptosis inducer Gasdermin-D (GSDMD), into their active, mature forms. In mouse models, aluminum hydroxide (Alum) activates caspase-1, leading to the maturation of IL-1β and IL-18 and enhancing their pro-inflammatory effects. Additionally, caspase-1 is involved in activating the NLRP3 inflammasome, which is crucial in a range of pathogen infections and metabolic disorders.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Kaushik, Deepak Kumar et al. "NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis." PloS one vol. 7,2 (2012): e32270.