Mouse Calcium Channel, Voltage Dependent, R-Type, Alpha 1E Subunit (CACNa1E) ELISA Kit-Sandwich

Voltage-sensitive calcium channels (VSCCs) enable the entry of calcium ions into excitable cells and are involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. The alpha-1E isoform is responsible for generating R-type calcium currents. These R-type calcium channels fall under the 'high-voltage activated' (HVA) group and can be inhibited by nickel. The Cacna1e gene encodes the CaV2.3 voltage-gated calcium channel, which serves multiple significant biological functions in mice. Mice lacking Cacna1e exhibit diminished responses to painful stimuli, suggesting that the CaV2.3 channel plays a crucial role in pain transmission. Furthermore, Cacna1e knockout mice display abnormalities in specific behavioral tests, such as a complete absence of the acute motor response to cocaine.