Mouse C-C Motif Chemokine 5 (CCL5) ELISA Kit-Sandwich

C-C motif chemokine 5 acts as a chemoattractant for blood monocytes, memory T-helper cells, and eosinophils, triggering histamine release from basophils and activating eosinophils. It may activate several chemokine receptors, including CCR1, CCR3, CCR4, and CCR5. In mice, CCL5 (C-C chemokine ligand 5) is involved in various physiological and pathological processes across multiple systems, including cardiac, neural, immune, and metabolic systems. CCL5 promotes inflammatory responses and myocardial damage by recruiting neutrophils and macrophages. It also plays a crucial role in the nervous system, particularly in the hippocampus and synaptic function. CCL5 knockout mice exhibit diminished learning and memory abilities, linked to a reduction in hippocampal synaptic structure and long-term potentiation (LTP). CCL5 supports synapse formation and memory function in the hippocampus by enhancing glucose metabolism and mitochondrial function.