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Mouse Breast Cancer Susceptibility Protein 2 (BRCA2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Breast Cancer Susceptibility Protein 2 (BRCA2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse BRCA2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
The Breast cancer type 2 susceptibility protein homolog (BRCA2) is essential for repairing double-strand breaks and facilitating homologous recombination. It interacts with RAD51 and enhances recombinational DNA repair by promoting RAD51 assembly on single-stranded DNA (ssDNA). BRCA2 targets RAD51 to ssDNA rather than double-stranded DNA, enabling RAD51 to replace replication protein-A (RPA) on ssDNA and stabilizing RAD51-ssDNA filaments by preventing ATP hydrolysis. In mice, BRCA2 plays a crucial role in reproduction. Research indicates that a deficiency in BRCA2 can lead to spermatogenesis disorders, specifically preventing sperm cells from proceeding to the second phase of meiosis (the first polar phase), ultimately resulting in infertility.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.