Mouse B-Cell Leukemia/Lymphoma 2 (Bcl2) ELISA Kit-Sandwich

Apoptosis regulator Bcl-2 inhibits apoptosis across various cell systems, including factor-dependent lymphohematopoietic and neural cells, by regulating mitochondrial membrane permeability. It operates within a feedback loop system with caspases, inhibiting their activity by either preventing the release of cytochrome c from the mitochondria or binding to the apoptosis-activating factor (APAF-1). Additionally, Bcl-2 acts as an inhibitor of autophagy by interacting with BECN1 and AMBRA1 under non-starvation conditions, thereby suppressing their autophagic functions. In mice, Bcl-2's functions include inhibiting apoptosis, regulating mitochondrial function, exerting anti-tumor effects, providing neuroprotection, contributing to immunoregulation, and participating in various physiological and pathological processes.