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Mouse ATPase, H+/K+ Exchanging Alpha Polypeptide (ATP4a) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse ATPase, H+/K+ Exchanging Alpha Polypeptide (ATP4a) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ATP4a in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Potassium-transporting ATPase alpha chain 1 is the catalytic subunit of the gastric H+/K+ ATPase pump, responsible for exchanging H+ ions for K+ ions across the apical membrane of parietal cells. In mice, the main function of Atp4a is to sustain gastric acid secretion and maintain the normal physiological condition of the gastric mucosa through the H+/K±ATPase α subunit it encodes. Mice deficient in Atp4a exhibit significant pathological changes in the gastric mucosa, including mucocele-like lesions and gastric mucosal metaplasia. These lesions resemble human gastric mucosal diseases, such as hypertrophic gastritis and gastric precancerous lesions, making Atp4a−/− mice valuable as a model for studying these conditions.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Li, Xianju et al. "A time-resolved multi-omic atlas of the developing mouse stomach." Nature communications vol. 9,1 4910. 21 Nov. 2018.