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Mouse Anti-Mouse Leptin (LEP) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for mouse leptin. It is affinity purified by protein A and protein G . It can be applied to WB, IHC, ICC and IP assays of mouse leptin.
Specifications
Target Information
Mouse Leptin is a protein hormone produced primarily by adipose tissue. It regulates energy homeostasis, neuroendocrine function, and reproduction by acting on the long-form leptin receptor (LepRb) in the brain. Leptin is encoded by the obese gene and is essential for maintaining energy balance and body weight. Its receptor, LepRb, is widely expressed in the hypothalamus and other brain regions, including the ventral tegmental area and the parabrachial nucleus. Leptin signaling is crucial for reducing food intake and body weight when administered centrally.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 2 years). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- McMurphy, Travis, et al. "The anti-tumor activity of a neutralizing nanobody targeting leptin receptor in a mouse model of melanoma." PloS one 9.2 (2014): e89895.