Mouse Annexin A1 (ANXA1) ELISA Kit-Sandwich

Annexin A1 plays crucial roles in the innate immune response by acting as an effector in glucocorticoid-mediated responses and regulating the inflammatory process. It is known for its anti-inflammatory properties, particularly in down-regulating the early phase of inflammation mediated by glucocorticoids. AnxA1 serves as a key anti-inflammatory protein by binding to the FPR2/ALFR receptor. Research indicates that AnxA1 can decrease the production of pro-inflammatory cytokines by neutrophils, promote neutrophil apoptosis, inhibit phospholipase A2 activity, and hinder fatty acid oxidation. Additionally, in mouse models of cerebral hemorrhage, AnxA1 reduces neuroinflammation and cerebral edema via the FPR2/p38/COX-2 pathway, improving short-term neurological outcomes. In the bone marrow, it helps maintain microenvironmental stability by aiding macrophages in the clearance of senescent neutrophils.