Mouse Aldehyde Dehydrogenase 1 Family, Member A1 (ALDH1A1) ELISA Kit-Sandwich

Aldh1a1 is a cytosolic dehydrogenase that catalyzes the irreversible oxidation of various aldehydes into their corresponding carboxylic acids. It functions downstream of retinol dehydrogenases, specifically oxidizing retinaldehyde into retinoic acid, which is the second step in the conversion of retinol (vitamin A) into retinoic acid. In mice, Aldh1a1 has diverse and crucial roles, including retinoic acid metabolism, lipid detoxification, neuroprotection, bone health, and involvement in cancer-related processes. In adult mice, Aldh1a1 is the primary enzyme responsible for retinoic acid metabolism, contributing to over 90% of retinoic acid production in the liver. Additionally, Aldh1a1 is expressed in the mouse brain, particularly in dopamine neurons of the substantia nigra, where it protects neurons from toxic metabolites by regulating dopamine metabolism. These functions highlight the essential role of Aldh1a1 in both metabolic and neuroprotective processes.