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Guinea Pig Anti-Rabbit Cluster of Differentiation 4 (CD4) Polyclonal Antibody
Product Overview
BioVenic guinea pig polyclonal antibody is specific for rabbit cluster of differentiation 4. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of rabbit cluster of differentiation 4.
Specifications
Target Information
Rabbit cluster of differentiation 4 (CD4) is a transmembrane glycoprotein expressed on immune cells, a core regulator of T-cell activation and antigen recognition. It features four conserved extracellular immunoglobulin-like domains, a single transmembrane region, and a cytoplasmic tail critical for signal transduction. It localizes predominantly to the plasma membrane of rabbit helper T lymphocytes, dendritic cells and monocytes, with negligible levels in non-immune cell populations. The protein mediates MHC class II molecule binding and TCR complex stabilization, with conserved motifs for recruiting tyrosine kinase Lck. Rabbit CD4 shares core functional domains with mammalian orthologs, and has distinct immune regulatory specificity differentiating it from CD8 and CD3.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.