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Bovine Apurinic/Apyrimidinic Endodeoxyribonuclease 1(APEX1) ELISA Kit-Sandwich

Name: Bovine Apurinic/Apyrimidinic Endodeoxyribonuclease 1(APEX1) ELISA Kit-Sandwich
SKU: EK12F47
Rating: 5 (1 reviews)

Cat. No.EK12F47

Product TypeAnimal Immunoassay Kits

Size

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Product Overview

BioVenic Bovine Apurinic/Apyrimidinic Endodeoxyribonuclease 1(APEX1) ELISA Kit-Sandwich is designed for the quantitative determination of Bovine Apurinic/Apyrimidinic Endodeoxyribonuclease 1(APEX1) in serum, plasma, tissue homogenate, cell culture supernatant, cell extract, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich

Specificity The assay kit is specific for Bovine APEX1.

Target Species Bovine

Species Reactivity Bovine

Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 10%

Assay Time Around 270 min

Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell extract, and other biological fluids.

Target Information

Bovine Apurinic/apyrimidinic endodeoxyribonuclease 1is encoded by the APEX1 gene in cattle. It is the main AP-endonuclease of the DNA base excision repair pathway. APEX1 plays a central role in base excision repair (BER) by removing apurinic/apyrimidinic (AP) sites-frequent DNA lesions caused by hydrolysis or DNA damage. These AP sites can prevent normal DNA replication and are considered pre-mutagenic lesions. Disruptions in APEX1's functions are associated with various malignancies and neurodegenerative diseases.

Target/Biomarker Bovine APEX1

Target Synonym apurinic/apyrimidinic endodeoxyribonuclease 1; APEN; BAP1; REF-1; DNA-(apurinic or apyrimidinic site) endonuclease; AP endonuclease 1; AP lyase; APEX nuclease (multifunctional DNA repair enzyme) 1; DNA-(apurinic or apyrimidinic site) lyase; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic endonuclease; redox factor-1

Gene ID 281630

UniProt ID P23196

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

Mangiapane, G. et al. Enzymatically active apurinic/apyrimidinic endodeoxyribonuclease 1 is released by mammalian cells through exosomes. The Journal of biological chemistry. 2021, 296: 100569.