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Atg5 Knockout Mouse Hippocampal Neuron Cell Line-HT22
Product Overview
Mouse Hippocampal Neuron Cell Line-HT22 is a subclone of HT-4 and is highly sensitive to glutamate, making it frequently used as a research model for glutamate-induced neurotoxicity. Through induced differentiation, HT-22 cells can exhibit characteristics closer to those of mature hippocampal neurons, thereby playing an important role in the study of neurodegenerative diseases, neuroinflammation, neuroprotection, and drug screening. The Atg5 gene in this cell line was knocked out by gene editing.
Specifications
Target Information
The Atg5 gene in this cell line was knocked out by gene editing. ATG5 is vital in a variety of physiological and pathological processes. For example, in B lymphocyte development, the absence of ATG5 leads to defects in B-1 B cells, affecting the proportion and function of B cell subsets. Furthermore, ATG5 also plays a key role in astrocyte differentiation; its overexpression can promote astrocyte generation, while its knockdown inhibits their differentiation.
Shipping and Storage
This product is shipped with dry ice. It's recommended to store the product with liquid nitrogen and never in a -20 °C or -80 °C refrigerator. Avoid repeated freezing and thawing of the product.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.